Combined modality treatment for rectal cancer.

Journal Article (Journal Article;Review)

Significant gains have been achieved in the integration of radiation therapy (RT) and chemotherapy with surgery in the management of patients with localized rectal cancer. Treatment combinations of RT and chemotherapy with surgery have evolved to neoadjuvant approaches of these modalities to enhance sphincter preservation, tumor control, and reduction of acute and late treatment-related morbidity. Although 5-fluorouracil (5-FU)-based chemotherapy in combination with RT remains the standard adjuvant therapy for rectal cancer, the integration of novel chemotherapeutic agents and biologic modulators is being actively investigated.

Full Text

Duke Authors

Cited Authors

  • Zhu, AX; Willett, CG

Published Date

  • February 2005

Published In

Volume / Issue

  • 32 / 1

Start / End Page

  • 103 - 112

PubMed ID

  • 15726512

International Standard Serial Number (ISSN)

  • 0093-7754

Digital Object Identifier (DOI)

  • 10.1053/j.seminoncol.2004.09.032


  • eng

Conference Location

  • United States