Development of postglucoprivic insulin-induced suckling and feeding in rats.
Journal Article (Journal Article)
Increased food or milk intake in response to insulin-induced hypoglycemia cannot be demonstrated in the rat until pups reach weaning age. However, when food and suckling are withheld from insulin-treated 5- to 25-day-old rats until their altered blood glucose levels return to normal, their rate of milk intake via suckling from their anesthetized dam is increased over saline-treated control pups. This postglucoprivic action of insulin could not be demonstrated in rats consuming wet mash until pups reached 25-30 days of age. Nonnutritive oral stimulation from dry suckling during the glucoprivic episode is sufficient to disrupt postglucoprivic suckling in 20-day-old rats. In contrast consuming a small quantity of wet mash became an effective inhibitor of postglucoprivic suckling only when pups reached 25 days of age. These data demonstrate the existence of an insulin-sensitive neural system for suckling and feeding in infant rats and point to the involvement of multiple and changing oral factors during development in insulin-induced postglucoprivic feeding.
Full Text
Duke Authors
Cited Authors
- Williams, CL; Blass, EM
Published Date
- July 1987
Published In
Volume / Issue
- 253 / 1 Pt 2
Start / End Page
- R121 - R127
PubMed ID
- 3300371
Electronic International Standard Serial Number (EISSN)
- 2163-5773
International Standard Serial Number (ISSN)
- 0002-9513
Digital Object Identifier (DOI)
- 10.1152/ajpregu.1987.253.1.r121
Language
- eng