Risperidone decreases craving and relapses in individuals with schizophrenia and cocaine dependence.
Journal Article (Clinical Trial;Journal Article)
OBJECTIVE: To examine the efficacy of atypical neuroleptics for decreasing craving and drug relapses during protracted withdrawal in individuals dually diagnosed with schizophrenia and cocaine dependence. METHOD: We conducted a 6-week, open-label pilot study comparing risperidone with typical neuroleptics in a sample of withdrawn cocaine-dependent schizophrenia patients. RESULTS: Preliminary results suggest that individuals treated with risperidone had significantly less cue-elicited craving and substance abuse relapses at study completion. Further, they showed a trend toward a greater reduction in negative and global symptoms of schizophrenia. CONCLUSION: Atypical neuroleptics may help reduce craving and relapses in this population. Future research should include more rigorous double-blind placebo-controlled studies with this class of medications.
Full Text
Duke Authors
Cited Authors
- Smelson, DA; Losonczy, MF; Davis, CW; Kaune, M; Williams, J; Ziedonis, D
Published Date
- September 2002
Published In
Volume / Issue
- 47 / 7
Start / End Page
- 671 - 675
PubMed ID
- 12355680
International Standard Serial Number (ISSN)
- 0706-7437
Digital Object Identifier (DOI)
- 10.1177/070674370204700710
Language
- eng
Conference Location
- United States