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CSF CRH in abstinent cocaine-dependent patients.

Publication ,  Journal Article
Roy, A; Bissette, G; Williams, R; Berman, J; Gonzalez, B
Published in: Psychiatry Res
March 25, 2003

Alterations in stress responsivity may be important in the vulnerability to become cocaine dependent. Thus, an index of hypothalamic-pituitary-adrenal (HPA) axis function was examined in abstinent cocaine-dependent patients. Cerebrospinal fluid (CSF) concentrations of corticotropin releasing factor (CRH) were determined in 29 abstinent cocaine-dependent patients and 66 normal controls. The results showed that there was no significant difference between the abstinent cocaine-dependent patients and normal controls for CSF CRH. Also, CSF CRH concentrations were not related to cocaine-craving scores in a cue-elicited cocaine-craving procedure. Thus, these data suggest that after protracted abstinence from cocaine there is no marked dysregulation of CRH systems as measured by CSF CRH concentrations.

Duke Scholars

Published In

Psychiatry Res

DOI

ISSN

0165-1781

Publication Date

March 25, 2003

Volume

117

Issue

3

Start / End Page

277 / 280

Location

Ireland

Related Subject Headings

  • Substance Withdrawal Syndrome
  • Psychiatry
  • Pituitary-Adrenal System
  • Male
  • Hypothalamo-Hypophyseal System
  • Hydrocortisone
  • Humans
  • Follow-Up Studies
  • Corticotropin-Releasing Hormone
  • Cocaine
 

Citation

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ICMJE
MLA
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Roy, A., Bissette, G., Williams, R., Berman, J., & Gonzalez, B. (2003). CSF CRH in abstinent cocaine-dependent patients. Psychiatry Res, 117(3), 277–280. https://doi.org/10.1016/s0165-1781(03)00040-4
Roy, Alec, Garth Bissette, Redford Williams, Jeffrey Berman, and Bienvenido Gonzalez. “CSF CRH in abstinent cocaine-dependent patients.Psychiatry Res 117, no. 3 (March 25, 2003): 277–80. https://doi.org/10.1016/s0165-1781(03)00040-4.
Roy A, Bissette G, Williams R, Berman J, Gonzalez B. CSF CRH in abstinent cocaine-dependent patients. Psychiatry Res. 2003 Mar 25;117(3):277–80.
Roy, Alec, et al. “CSF CRH in abstinent cocaine-dependent patients.Psychiatry Res, vol. 117, no. 3, Mar. 2003, pp. 277–80. Pubmed, doi:10.1016/s0165-1781(03)00040-4.
Roy A, Bissette G, Williams R, Berman J, Gonzalez B. CSF CRH in abstinent cocaine-dependent patients. Psychiatry Res. 2003 Mar 25;117(3):277–280.
Journal cover image

Published In

Psychiatry Res

DOI

ISSN

0165-1781

Publication Date

March 25, 2003

Volume

117

Issue

3

Start / End Page

277 / 280

Location

Ireland

Related Subject Headings

  • Substance Withdrawal Syndrome
  • Psychiatry
  • Pituitary-Adrenal System
  • Male
  • Hypothalamo-Hypophyseal System
  • Hydrocortisone
  • Humans
  • Follow-Up Studies
  • Corticotropin-Releasing Hormone
  • Cocaine