CSF CRH in abstinent cocaine-dependent patients.

Journal Article (Journal Article)

Alterations in stress responsivity may be important in the vulnerability to become cocaine dependent. Thus, an index of hypothalamic-pituitary-adrenal (HPA) axis function was examined in abstinent cocaine-dependent patients. Cerebrospinal fluid (CSF) concentrations of corticotropin releasing factor (CRH) were determined in 29 abstinent cocaine-dependent patients and 66 normal controls. The results showed that there was no significant difference between the abstinent cocaine-dependent patients and normal controls for CSF CRH. Also, CSF CRH concentrations were not related to cocaine-craving scores in a cue-elicited cocaine-craving procedure. Thus, these data suggest that after protracted abstinence from cocaine there is no marked dysregulation of CRH systems as measured by CSF CRH concentrations.

Full Text

Duke Authors

Cited Authors

  • Roy, A; Bissette, G; Williams, R; Berman, J; Gonzalez, B

Published Date

  • March 25, 2003

Published In

Volume / Issue

  • 117 / 3

Start / End Page

  • 277 - 280

PubMed ID

  • 12686370

International Standard Serial Number (ISSN)

  • 0165-1781

Digital Object Identifier (DOI)

  • 10.1016/s0165-1781(03)00040-4


  • eng

Conference Location

  • Ireland