Redistribution of canine left ventricular myocardial blood flow in unloaded systole.

Journal Article (Journal Article)

The left coronary arteries of dogs were cannulated and perfused with blood from support dogs. The experimental hearts were unloaded by severing the aortas to maximize strains and minimize fiber stress. In each heart we compared the transmural distribution of blood flow in two states: (1) provision of perfusion pressure (40 mm Hg) only during systole and then (2) provision of perfusion pressure throughout the cardiac cycle. The distribution of flow in each of these perfusion states was labeled with a diffusible radioisotope (42K or 86Rb, one labeling the first state; the other labeling the second). Quantitative, paired autoradiography was used to visualize the two flow distributions. The differences between the two distributions after standardization was plotted as differences between activity vs. depth in the myocardium (r = 0.91). This was fitted with a line by least squares, the slope of which was significantly different from zero at the 0.005 level. The magnitude of the gradient of the systolic flow was represented by the ratio of deep to shallow flow. The mean of these ratios was 0.54 +/- 0.12 (95% confidence interval). A graphical analysis shows that the data are consistent with a gradient of extravascular compression across the left ventricular wall.

Full Text

Duke Authors

Cited Authors

  • Williams, RB; Tremer, HM; Sobin, SS

Published Date

  • July 1981

Published In

Volume / Issue

  • 49 / 1

Start / End Page

  • 203 - 211

PubMed ID

  • 7237693

International Standard Serial Number (ISSN)

  • 0009-7330

Digital Object Identifier (DOI)

  • 10.1161/01.res.49.1.203


  • eng

Conference Location

  • United States