The role of GABAB receptor activation in absence seizures of lethargic (lh/lh) mice.
Published
Journal Article
Lethargic (lh/lh) mice, which function as an animal model of absence seizures, have spontaneous seizures that have behavioral and electrographic features and anticonvulsant sensitivity similar to those of human absence seizures. Antagonists of the gamma-aminobutyric acidB (GABAB) receptor suppressed these seizures in lethargic mice, whereas agonists of GABAB receptors exacerbated them. Furthermore, GABAB receptor binding and synaptically evoked GABAB receptor-mediated inhibition of N-methyl-D-aspartate responses were selectively increased in lh/lh mice. Therefore, enhanced GABAB receptor-mediated synaptic responses may underlie absence seizures in lh/lh mice, and GABAB receptor antagonists hold promise as anticonvulsants for absence seizures.
Full Text
Duke Authors
Cited Authors
- Hosford, DA; Clark, S; Cao, Z; Wilson, WA; Lin, FH; Morrisett, RA; Huin, A
Published Date
- July 1992
Published In
Volume / Issue
- 257 / 5068
Start / End Page
- 398 - 401
PubMed ID
- 1321503
Pubmed Central ID
- 1321503
Electronic International Standard Serial Number (EISSN)
- 1095-9203
International Standard Serial Number (ISSN)
- 0036-8075
Digital Object Identifier (DOI)
- 10.1126/science.1321503
Language
- eng