The role of GABAB receptor activation in absence seizures of lethargic (lh/lh) mice.

Journal Article (Journal Article)

Lethargic (lh/lh) mice, which function as an animal model of absence seizures, have spontaneous seizures that have behavioral and electrographic features and anticonvulsant sensitivity similar to those of human absence seizures. Antagonists of the gamma-aminobutyric acidB (GABAB) receptor suppressed these seizures in lethargic mice, whereas agonists of GABAB receptors exacerbated them. Furthermore, GABAB receptor binding and synaptically evoked GABAB receptor-mediated inhibition of N-methyl-D-aspartate responses were selectively increased in lh/lh mice. Therefore, enhanced GABAB receptor-mediated synaptic responses may underlie absence seizures in lh/lh mice, and GABAB receptor antagonists hold promise as anticonvulsants for absence seizures.

Full Text

Duke Authors

Cited Authors

  • Hosford, DA; Clark, S; Cao, Z; Wilson, WA; Lin, FH; Morrisett, RA; Huin, A

Published Date

  • July 1992

Published In

Volume / Issue

  • 257 / 5068

Start / End Page

  • 398 - 401

PubMed ID

  • 1321503

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1321503


  • eng