Increased ectopic action potential generation accompanies epileptogenesis in vitro.

Journal Article (Journal Article)

We studied changes in the characteristics of action potentials of CA3 pyramidal cells accompanying electrographic seizure (EGS) induction, using an in vitro model similar to kindling. We found an increased propensity to fire action potentials which lack EPSPs or other triggering depolarizing potentials. Such 'baseline spikes' appear to be initiated at a site electrically distant from the soma.

Full Text

Duke Authors

Cited Authors

  • Stasheff, SF; Wilson, WA

Published Date

  • March 1990

Published In

Volume / Issue

  • 111 / 1-2

Start / End Page

  • 144 - 150

PubMed ID

  • 2336180

Electronic International Standard Serial Number (EISSN)

  • 1872-7972

International Standard Serial Number (ISSN)

  • 0304-3940

Digital Object Identifier (DOI)

  • 10.1016/0304-3940(90)90359-h


  • eng