NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model.

Journal Article (Journal Article)

In an electrographic model of seizures in the hippocampal slice, both of the N-methyl-D-aspartate (NMDA) antagonists 2-amino-5-phosphonovaleric acid and 5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine maleate (MK-801) prevented the progressive development of seizures but did not block previously induced seizures. Thus, a process dependent on the NMDA receptor-ionophore complex establishes a long-lasting, seizure-prone state; thereafter the seizures depend on non-NMDA receptor-ionophore mechanisms. This suggests that there is an important distinction between epileptogenesis and seizure expression and between antiepileptogenic and anticonvulsant pharmacological agents.

Full Text

Duke Authors

Cited Authors

  • Stasheff, SF; Anderson, WW; Clark, S; Wilson, WA

Published Date

  • August 1, 1989

Published In

Volume / Issue

  • 245 / 4918

Start / End Page

  • 648 - 651

PubMed ID

  • 2569762

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.2569762


  • eng