Suppression of repetitive firing of neurons by diphenylbarbituric acid.

Published

Journal Article

A slow outward current has been demonstrated in Aplysia giant neurons which serves to suppress repetitive firing. The barbiturates phenobarbital and pentobarbital enhance the slow outward current and the suppression of repetitive firing. In this study, the effects of diphenylbarbituric acid, which shows anticonvulsant activity in mice and rats but possesses minimal sedative properties, were tested on slow outward current and firing behavior. Diphenylbarbituric acid enhances slow outward current and suppresses repetitive firing at lower concentrations than phenobarbital and pentobarbital. Because diphenylbarbituric acid is effective at enhancing slow outward current but does not produce sedation, this property of barbiturates is apparently not associated with the sedative properties of these drugs, but rather is important for the anticonvulsant effects.

Full Text

Duke Authors

Cited Authors

  • Huguenard, JR; Wilson, WA

Published Date

  • January 1, 1985

Published In

Volume / Issue

  • 232 / 1

Start / End Page

  • 228 - 231

PubMed ID

  • 3965694

Pubmed Central ID

  • 3965694

Electronic International Standard Serial Number (EISSN)

  • 1521-0103

International Standard Serial Number (ISSN)

  • 0022-3565

Language

  • eng