Prolonged inhibition in burst firing neurons: synaptic inactivation of the slow regenerative inward current.
Journal Article (Journal Article)
By using voltage clamping and microiontophoretic techniques, it has been found that the prolonged cholinergic and dopaminergic inhibition seen in Aplysia burst firing neurons occludes the inward current on which slow oscillations depend. It also mimics the temperature and ionic sensitivity of that inward current. This prolonged inhibition, which cannot be inverted and is insensitive to extracellular potassium changes, thus appears to result from a synaptically produced inactivation of the regenerative slow inward current underlying bursting.
Full Text
Duke Authors
Cited Authors
- Wilson, WA; Wachtel, H
Published Date
- November 1, 1978
Published In
Volume / Issue
- 202 / 4369
Start / End Page
- 772 - 775
PubMed ID
- 715442
Electronic International Standard Serial Number (EISSN)
- 1095-9203
International Standard Serial Number (ISSN)
- 0036-8075
Digital Object Identifier (DOI)
- 10.1126/science.715442
Language
- eng