Synaptic mechanism of pentylenetetrazole: selectivity for chloride conductance.
Published
Journal Article
In the neurons of Aplysia californica pentylenetetrazole (2 millimolar) greatly reduced chloride-dependent responses to the iontophoresis of putative transmitters. At the same concentration, pentylenetetrazole caused less attenuation of the other iontophoretic responses and had minimal membrane effects. Several convulsants have been observed to have a similar selectivity for the chloride conductance. A common mechanism of convulsant action--reduction of transmitter-induced chloride conductances--is hypothesized.
Full Text
Duke Authors
Cited Authors
- Pellmar, TC; Wilson, WA
Published Date
- August 1, 1977
Published In
Volume / Issue
- 197 / 4306
Start / End Page
- 912 - 914
PubMed ID
- 887932
Pubmed Central ID
- 887932
Electronic International Standard Serial Number (EISSN)
- 1095-9203
International Standard Serial Number (ISSN)
- 0036-8075
Digital Object Identifier (DOI)
- 10.1126/science.887932
Language
- eng