Synaptic mechanism of pentylenetetrazole: selectivity for chloride conductance.

Journal Article (Journal Article)

In the neurons of Aplysia californica pentylenetetrazole (2 millimolar) greatly reduced chloride-dependent responses to the iontophoresis of putative transmitters. At the same concentration, pentylenetetrazole caused less attenuation of the other iontophoretic responses and had minimal membrane effects. Several convulsants have been observed to have a similar selectivity for the chloride conductance. A common mechanism of convulsant action--reduction of transmitter-induced chloride conductances--is hypothesized.

Full Text

Duke Authors

Cited Authors

  • Pellmar, TC; Wilson, WA

Published Date

  • August 1, 1977

Published In

Volume / Issue

  • 197 / 4306

Start / End Page

  • 912 - 914

PubMed ID

  • 887932

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.887932

Language

  • eng