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Effect of nitrous oxide on cerebral blood velocity while reclining and standing.

Publication ,  Journal Article
Mathew, RJ; Wilson, WH; Humphreys, D; Lowe, JV
Published in: Biol Psychiatry
May 1, 1997

Cerebral blood velocity (CBV) (measured with transcranial Doppler, TCD) and other physiological and rating scale indices were measured before, during, and after inhaling a mixture of 40% nitrous oxide/oxygen and 40% nitrogen/oxygen, given during two separate visits in 7 normal male volunteers. During nitrous oxide/oxygen but not nitrogen/oxygen inhalation, CBV and euphoria increased significantly with minimal changes in other physiological indices except an increase in pulse rate after nitrous oxide/oxygen. In another 7 male volunteers, similar measurements were obtained while lying down and standing up during nitrous oxide/oxygen mixture and nitrogen/oxygen mixture inhalations, given during two separate visits. Nitrous oxide/oxygen inhalation produced significant CBV increase, which showed nonsignificant decrease of no clinical significance during standing up. There were no significant postural changes in blood pressure. Standing up during nitrous oxide/oxygen inhalation was associated with significant though mild dizziness.

Duke Scholars

Published In

Biol Psychiatry

DOI

ISSN

0006-3223

Publication Date

May 1, 1997

Volume

41

Issue

9

Start / End Page

979 / 984

Location

United States

Related Subject Headings

  • Ultrasonography, Doppler, Transcranial
  • Psychiatry
  • Posture
  • Nitrous Oxide
  • Male
  • Illicit Drugs
  • Humans
  • Euphoria
  • Brain
  • Blood Pressure
 

Citation

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Mathew, R. J., Wilson, W. H., Humphreys, D., & Lowe, J. V. (1997). Effect of nitrous oxide on cerebral blood velocity while reclining and standing. Biol Psychiatry, 41(9), 979–984. https://doi.org/10.1016/S0006-3223(96)00159-X
Mathew, R. J., W. H. Wilson, D. Humphreys, and J. V. Lowe. “Effect of nitrous oxide on cerebral blood velocity while reclining and standing.Biol Psychiatry 41, no. 9 (May 1, 1997): 979–84. https://doi.org/10.1016/S0006-3223(96)00159-X.
Mathew RJ, Wilson WH, Humphreys D, Lowe JV. Effect of nitrous oxide on cerebral blood velocity while reclining and standing. Biol Psychiatry. 1997 May 1;41(9):979–84.
Mathew, R. J., et al. “Effect of nitrous oxide on cerebral blood velocity while reclining and standing.Biol Psychiatry, vol. 41, no. 9, May 1997, pp. 979–84. Pubmed, doi:10.1016/S0006-3223(96)00159-X.
Mathew RJ, Wilson WH, Humphreys D, Lowe JV. Effect of nitrous oxide on cerebral blood velocity while reclining and standing. Biol Psychiatry. 1997 May 1;41(9):979–984.
Journal cover image

Published In

Biol Psychiatry

DOI

ISSN

0006-3223

Publication Date

May 1, 1997

Volume

41

Issue

9

Start / End Page

979 / 984

Location

United States

Related Subject Headings

  • Ultrasonography, Doppler, Transcranial
  • Psychiatry
  • Posture
  • Nitrous Oxide
  • Male
  • Illicit Drugs
  • Humans
  • Euphoria
  • Brain
  • Blood Pressure