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Cerebral vasodilation and vasoconstriction associated with acute anxiety.

Publication ,  Journal Article
Mathew, RJ; Wilson, WH; Humphreys, D; Lowe, JV; Wiethe, KE
Published in: Biol Psychiatry
April 1, 1997

A randomized, between-groups, repeated measures design was used to evaluate changes in cerebral blood flow (CBF), rating scales, and physiologic indices under resting conditions, during 5% CO2 inhalation in combination with epinephrine or saline infusions, in generalized anxiety disorder patients and controls. Subjects were divided into those with decreased anxiety and mild and more severe anxiety increase. The first group was found to have most pronounced CBF increase during CO2 inhalation, with the second group showing less marked increase, and the last group the least increase. In animals, sympathetic activation limits hypercapnic cerebral vasodilation. Thus, the restricted hypercapnic cerebral vasodilation during severe anxiety may be mediated through cervical sympathetic fibers, which innervate cerebral vessels.

Duke Scholars

Published In

Biol Psychiatry

DOI

ISSN

0006-3223

Publication Date

April 1, 1997

Volume

41

Issue

7

Start / End Page

782 / 795

Location

United States

Related Subject Headings

  • Xenon Radioisotopes
  • Vasodilation
  • Vasoconstriction
  • Sympathetic Nervous System
  • Regional Blood Flow
  • Radionuclide Imaging
  • Psychiatry
  • Personality Assessment
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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Mathew, R. J., Wilson, W. H., Humphreys, D., Lowe, J. V., & Wiethe, K. E. (1997). Cerebral vasodilation and vasoconstriction associated with acute anxiety. Biol Psychiatry, 41(7), 782–795. https://doi.org/10.1016/S0006-3223(96)00178-3
Mathew, R. J., W. H. Wilson, D. Humphreys, J. V. Lowe, and K. E. Wiethe. “Cerebral vasodilation and vasoconstriction associated with acute anxiety.Biol Psychiatry 41, no. 7 (April 1, 1997): 782–95. https://doi.org/10.1016/S0006-3223(96)00178-3.
Mathew RJ, Wilson WH, Humphreys D, Lowe JV, Wiethe KE. Cerebral vasodilation and vasoconstriction associated with acute anxiety. Biol Psychiatry. 1997 Apr 1;41(7):782–95.
Mathew, R. J., et al. “Cerebral vasodilation and vasoconstriction associated with acute anxiety.Biol Psychiatry, vol. 41, no. 7, Apr. 1997, pp. 782–95. Pubmed, doi:10.1016/S0006-3223(96)00178-3.
Mathew RJ, Wilson WH, Humphreys D, Lowe JV, Wiethe KE. Cerebral vasodilation and vasoconstriction associated with acute anxiety. Biol Psychiatry. 1997 Apr 1;41(7):782–795.
Journal cover image

Published In

Biol Psychiatry

DOI

ISSN

0006-3223

Publication Date

April 1, 1997

Volume

41

Issue

7

Start / End Page

782 / 795

Location

United States

Related Subject Headings

  • Xenon Radioisotopes
  • Vasodilation
  • Vasoconstriction
  • Sympathetic Nervous System
  • Regional Blood Flow
  • Radionuclide Imaging
  • Psychiatry
  • Personality Assessment
  • Middle Aged
  • Male