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Acute changes in cranial blood flow after cocaine hydrochloride.

Publication ,  Journal Article
Mathew, RJ; Wilson, WH; Lowe, JV; Humphries, D
Published in: Biol Psychiatry
October 1, 1996

Cerebral blood flow (CBF) was measured with the 133Xenon inhalation technique and forehead skin flow with laser Doppler, before and twice after 0.3 milligram/kilogram of cocaine hydrochloride and a placebo given intravenously to six cocaine abusers, during two visits, separated by a minimum of one week. After cocaine, subjects showed significant increases in intoxication and tension. Systolic blood pressure and pulse rate also increased significantly after the drug but not after the placebo. CBF, with and without correction for end-tidal CO2, showed increases in left and right hemisphere after cocaine. The CBF increase was maximal in frontal, central and parietal regions. CBF changes correlated only with changes in a rated level of intoxication. Forehead skin flow did not change after cocaine or placebo. In habitual cocaine abusers, 0.3 mg/kg of cocaine, given intravenously produced increased CBF and no changes in forehead skin flow.

Duke Scholars

Published In

Biol Psychiatry

DOI

ISSN

0006-3223

Publication Date

October 1, 1996

Volume

40

Issue

7

Start / End Page

609 / 616

Location

United States

Related Subject Headings

  • Xenon Radioisotopes
  • Skin
  • Regional Blood Flow
  • Reference Values
  • Radionuclide Imaging
  • Psychiatry
  • Personality Inventory
  • Opioid-Related Disorders
  • Narcotics
  • Male
 

Citation

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Mathew, R. J., Wilson, W. H., Lowe, J. V., & Humphries, D. (1996). Acute changes in cranial blood flow after cocaine hydrochloride. Biol Psychiatry, 40(7), 609–616. https://doi.org/10.1016/0006-3223(95)00033-x
Mathew, R. J., W. H. Wilson, J. V. Lowe, and D. Humphries. “Acute changes in cranial blood flow after cocaine hydrochloride.Biol Psychiatry 40, no. 7 (October 1, 1996): 609–16. https://doi.org/10.1016/0006-3223(95)00033-x.
Mathew RJ, Wilson WH, Lowe JV, Humphries D. Acute changes in cranial blood flow after cocaine hydrochloride. Biol Psychiatry. 1996 Oct 1;40(7):609–16.
Mathew, R. J., et al. “Acute changes in cranial blood flow after cocaine hydrochloride.Biol Psychiatry, vol. 40, no. 7, Oct. 1996, pp. 609–16. Pubmed, doi:10.1016/0006-3223(95)00033-x.
Mathew RJ, Wilson WH, Lowe JV, Humphries D. Acute changes in cranial blood flow after cocaine hydrochloride. Biol Psychiatry. 1996 Oct 1;40(7):609–616.
Journal cover image

Published In

Biol Psychiatry

DOI

ISSN

0006-3223

Publication Date

October 1, 1996

Volume

40

Issue

7

Start / End Page

609 / 616

Location

United States

Related Subject Headings

  • Xenon Radioisotopes
  • Skin
  • Regional Blood Flow
  • Reference Values
  • Radionuclide Imaging
  • Psychiatry
  • Personality Inventory
  • Opioid-Related Disorders
  • Narcotics
  • Male