beta-Endorphin enhances the replication of neurotropic human immunodeficiency virus in fetal perivascular microglia.

Published

Journal Article

The effect of an endogenous opiate, beta-endorphin, on the replication of HIV was investigated in brain perivascular microglia. Beta-endorphin enhanced the synthesis of p-24 antigen and transactivation of HIV promoter. Dialysed culture supernatants of endorphin-treated microglia re-activated latent HIV infection. These culture supernatants showed elevated levels of interleukin-1 beta, IL-6 and tumor necrosis factor alpha. Sub-optimal concentration of beta-endorphin potentiated GP-120-induced synthesis of these cytokines. Nalaxone reversed beta-endorphin-induced, but not GP-120-induced, cytokine production and enhanced HIV replication. These results suggest that endogenous opiates may contribute to the progression of AIDS dementia complex.

Full Text

Duke Authors

Cited Authors

  • Sundar, KS; Kamaraju, LS; Dingfelder, J; McMahon, J; Gollapudi, S; Wilson, WH; Kong, LY; Hong, JS; Weiss, JM; Lee, JE

Published Date

  • August 1995

Published In

Volume / Issue

  • 61 / 1

Start / End Page

  • 97 - 104

PubMed ID

  • 7560019

Pubmed Central ID

  • 7560019

Electronic International Standard Serial Number (EISSN)

  • 1872-8421

International Standard Serial Number (ISSN)

  • 0165-5728

Digital Object Identifier (DOI)

  • 10.1016/0165-5728(95)00089-k

Language

  • eng