beta-Endorphin enhances the replication of neurotropic human immunodeficiency virus in fetal perivascular microglia.
The effect of an endogenous opiate, beta-endorphin, on the replication of HIV was investigated in brain perivascular microglia. Beta-endorphin enhanced the synthesis of p-24 antigen and transactivation of HIV promoter. Dialysed culture supernatants of endorphin-treated microglia re-activated latent HIV infection. These culture supernatants showed elevated levels of interleukin-1 beta, IL-6 and tumor necrosis factor alpha. Sub-optimal concentration of beta-endorphin potentiated GP-120-induced synthesis of these cytokines. Nalaxone reversed beta-endorphin-induced, but not GP-120-induced, cytokine production and enhanced HIV replication. These results suggest that endogenous opiates may contribute to the progression of AIDS dementia complex.
Sundar, KS; Kamaraju, LS; Dingfelder, J; McMahon, J; Gollapudi, S; Wilson, WH; Kong, LY; Hong, JS; Weiss, JM; Lee, JE
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