Effects of marijuana on performance of a computerized cognitive-neuromotor test battery.

Journal Article (Clinical Trial;Journal Article)

To evaluate the sensitivity of a computerized cognitive-neuromotor test battery in assessing the effects of marijuana (delta-9-tetrahydrocannabinol [THC]), we conducted a study of 10 healthy male volunteers who were experienced marijuana smokers. After extensive training on the performance tasks, each subject was tested on three separate days after smoking a cigarette containing either 1.75% THC, 3.55% THC, or placebo according to a randomized double-blind repeated measures design. Testing was carried out before smoking and 30, 90, and 150 minutes after smoking the cigarette. Of the five tasks employed, the digit-symbol substitution test with memory and the reaction time task were the measures most sensitive to effects of marijuana. We examined the usefulness of the coefficient of variation and effect size as indices of sensitivity to be used across different types of tasks.

Full Text

Duke Authors

Cited Authors

  • Wilson, WH; Ellinwood, EH; Mathew, RJ; Johnson, K

Published Date

  • February 1994

Published In

Volume / Issue

  • 51 / 2

Start / End Page

  • 115 - 125

PubMed ID

  • 8022946

International Standard Serial Number (ISSN)

  • 0165-1781

Digital Object Identifier (DOI)

  • 10.1016/0165-1781(94)90031-0


  • eng

Conference Location

  • Ireland