RU486 in depression.


Journal Article

RU486 is a synthetic glucocorticoid antagonist. The authors used RU486 to examine the hypothesis that the elevated plasma cortisol and ACTH in patients is due to suprahypophyseal stimulation of the anterior pituitary. Seven patients and matched controls were studied before and after the administration of RU486. RU486 produced an increase in HPA activity in depressed patients. Thus providing support for the hypothesis that there is increased suprahypophyseal stimulation of the anterior pituitary.

Full Text

Duke Authors

Cited Authors

  • Krishnan, KR; Reed, D; Wilson, WH; Saunders, WB; Ritchie, JC; Nemeroff, CB; Carroll, BJ

Published Date

  • 1992

Published In

Volume / Issue

  • 16 / 6

Start / End Page

  • 913 - 920

PubMed ID

  • 1325068

Pubmed Central ID

  • 1325068

International Standard Serial Number (ISSN)

  • 0278-5846

Digital Object Identifier (DOI)

  • 10.1016/0278-5846(92)90109-r


  • eng

Conference Location

  • England