Changes in cerebral blood velocity after intravenous diazepam.


Journal Article

Cerebral blood velocity (CBV) was measured with transcranial Doppler in 6 normal right-handed male volunteers before and for 50 min after an intravenous injection of 0.1 mg/kg of diazepam and normal saline during 2 separate visits to the laboratory. Blood pressure, pulse rate, end tidal levels of carbon dioxide and mood changes were quantified before and after the injections. Diazepam injection was associated with significant increases in fatigue and sleepiness. There were no significant changes in end tidal carbon dioxide, respiration, pulse rate, and blood pressure after the injection. Postdiazepam CBV was significantly lower following diazepam compared to CBV following placebo.

Full Text

Duke Authors

Cited Authors

  • Mathew, RJ; Wilson, WH; Humphreys, DF; Lowe, JV; Wiethe, KE

Published Date

  • April 1, 1992

Published In

Volume / Issue

  • 31 / 7

Start / End Page

  • 690 - 697

PubMed ID

  • 1599986

Pubmed Central ID

  • 1599986

International Standard Serial Number (ISSN)

  • 0006-3223

Digital Object Identifier (DOI)

  • 10.1016/0006-3223(92)90278-8


  • eng

Conference Location

  • United States