Circadian rhythm of adrenergic regulation of adrenocorticotropin and cortisol secretion in man.


Journal Article

The effects of the alpha-adrenergic agonist methoxamine on the human hypothalamic-pituitary-adrenal axis was assessed by a placebo-controlled study in the morning and one in the evening. A 5-mg iv bolus dose of methoxamine in normal subjects caused a significant rise in plasma ACTH and cortisol concentrations in the morning study. However, no significant change in plasma cortisol or ACTH concentrations was noted during the evening study. These studies suggest the existence of a diurnal variation in alpha 1-adrenergic regulation of the hypothalamic-pituitary-adrenal axis.

Full Text

Duke Authors

Cited Authors

  • Naylor, MR; Krishnan, KR; Manepalli, AN; Ritchie, JC; Wilson, WH; Carroll, BJ

Published Date

  • August 1988

Published In

Volume / Issue

  • 67 / 2

Start / End Page

  • 404 - 406

PubMed ID

  • 2839538

Pubmed Central ID

  • 2839538

International Standard Serial Number (ISSN)

  • 0021-972X

Digital Object Identifier (DOI)

  • 10.1210/jcem-67-2-404


  • eng

Conference Location

  • United States