Hyperoxia during reperfusion is a factor in reperfusion injury.


Journal Article

Imposition of ischemia should result in accumulation of lactic acid with an attendant drop in pH. Subsequent reperfusion would result in hyperoxia, in the affected tissue, due to the Bohr Effect. O2- should therefore be produced in greater than normal amounts, due to this transient hyperoxia, and may contribute to reperfusion injury. Tissue acidification, during extreme exercise or in diabetes mellitus, may similarly lead to hyperoxia and to tissue damage by O2-.

Full Text

Cited Authors

  • Wolbarsht, ML; Fridovich, I

Published Date

  • January 1989

Published In

Volume / Issue

  • 6 / 1

Start / End Page

  • 61 - 62

PubMed ID

  • 2536344

Pubmed Central ID

  • 2536344

Electronic International Standard Serial Number (EISSN)

  • 1873-4596

International Standard Serial Number (ISSN)

  • 0891-5849

Digital Object Identifier (DOI)

  • 10.1016/0891-5849(89)90161-5


  • eng