Skip to main content

Effects of peroneal nerve stimulation on hypothalamic stimulation-induced ventricular arrhythmias in rabbits.

Publication ,  Journal Article
Zhou, X; Wolf, PD; Smith, WM; Blanchard, SM; Ideker, RE
Published in: The American journal of physiology
November 1994

We tested the hypothesis that peripheral afferent nerve stimulation decreases the incidence of ventricular arrhythmias induced by central nervous system stimulation. The hypothalamus in each of 24 anesthetized rabbits (12 with anterior myocardial ischemia) was electrically stimulated for 10 s with 10-min intervals between each of six consecutive stimulation episodes. The left peroneal nerves were electrically stimulated for 15 min beginning 5 min after the second hypothalamic stimulation episode in six ischemic and six nonischemic rabbits. Cardiac rhythm was monitored with the electrocardiogram lead I and atrial and ventricular electrograms. Hypothalamic stimulation alone induced ventricular arrhythmias [mean no. of arrhythmic beats occurring during 3rd and 4th hypothalamic stimulation episodes: nonischemic animals, 20 +/- 8; ischemic animals, 62 +/- 41 (P < 0.05 by unpaired t-test)]. Peroneal nerve stimulation reduced the number of arrhythmic beats induced by hypothalamic stimulation in nonischemic animals (6 +/- 5; P < 0.05 vs. without peroneal stimulation) and prevented an increase in arrhythmic beats during ischemia (21 +/- 16). Thus peripheral nerve stimulation decreased the number of ventricular arrhythmic beats induced by repeated hypothalamic stimulation in both ischemic and normal rabbit hearts and may be important in the prevention of arrhythmias in patients.

Duke Scholars

Published In

The American journal of physiology

DOI

EISSN

2163-5773

ISSN

0002-9513

Publication Date

November 1994

Volume

267

Issue

5 Pt 2

Start / End Page

H2032 / H2041

Related Subject Headings

  • Time Factors
  • Reference Values
  • Rabbits
  • Peroneal Nerve
  • Myocardial Ischemia
  • Hypothalamus
  • Humans
  • Heart Ventricles
  • Heart Rate
  • Electroencephalography
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhou, X., Wolf, P. D., Smith, W. M., Blanchard, S. M., & Ideker, R. E. (1994). Effects of peroneal nerve stimulation on hypothalamic stimulation-induced ventricular arrhythmias in rabbits. The American Journal of Physiology, 267(5 Pt 2), H2032–H2041. https://doi.org/10.1152/ajpheart.1994.267.5.h2032
Zhou, X., P. D. Wolf, W. M. Smith, S. M. Blanchard, and R. E. Ideker. “Effects of peroneal nerve stimulation on hypothalamic stimulation-induced ventricular arrhythmias in rabbits.The American Journal of Physiology 267, no. 5 Pt 2 (November 1994): H2032–41. https://doi.org/10.1152/ajpheart.1994.267.5.h2032.
Zhou X, Wolf PD, Smith WM, Blanchard SM, Ideker RE. Effects of peroneal nerve stimulation on hypothalamic stimulation-induced ventricular arrhythmias in rabbits. The American journal of physiology. 1994 Nov;267(5 Pt 2):H2032–41.
Zhou, X., et al. “Effects of peroneal nerve stimulation on hypothalamic stimulation-induced ventricular arrhythmias in rabbits.The American Journal of Physiology, vol. 267, no. 5 Pt 2, Nov. 1994, pp. H2032–41. Epmc, doi:10.1152/ajpheart.1994.267.5.h2032.
Zhou X, Wolf PD, Smith WM, Blanchard SM, Ideker RE. Effects of peroneal nerve stimulation on hypothalamic stimulation-induced ventricular arrhythmias in rabbits. The American journal of physiology. 1994 Nov;267(5 Pt 2):H2032–H2041.

Published In

The American journal of physiology

DOI

EISSN

2163-5773

ISSN

0002-9513

Publication Date

November 1994

Volume

267

Issue

5 Pt 2

Start / End Page

H2032 / H2041

Related Subject Headings

  • Time Factors
  • Reference Values
  • Rabbits
  • Peroneal Nerve
  • Myocardial Ischemia
  • Hypothalamus
  • Humans
  • Heart Ventricles
  • Heart Rate
  • Electroencephalography