Ectopic synaptogenesis in the mammalian retina caused by rod photoreceptor-specific mutations.
Publication
, Journal Article
Peng, YW; Hao, Y; Petters, RM; Wong, F
Published in: Nat Neurosci
November 2000
In addition to rod photoreceptor loss, many mutations in rod photoreceptor-specific genes cause degeneration of other neuronal types. Identifying mechanisms of cell-cell interactions initiated by rod-specific mutations and affecting other retinal cells is important for understanding the pathogenesis and progression of retinal degeneration. Here we show in animals with rod and cone degeneration due to mutations in the genes encoding rhodopsin and cGMP phosphodiesterase beta-subunit (PDE-beta) respectively, that rod bipolar cells received ectopic synapses from cones in the absence of rods. Thus, synaptic plasticity links certain rod-specific mutations to retina-wide structural alterations that involve different types of neurons.
Duke Scholars
Published In
Nat Neurosci
DOI
ISSN
1097-6256
Publication Date
November 2000
Volume
3
Issue
11
Start / End Page
1121 / 1127
Location
United States
Related Subject Headings
- Synapses
- Swine
- Rhodopsin
- Retinal Rod Photoreceptor Cells
- Retinal Cone Photoreceptor Cells
- Retina
- Phosphoric Diester Hydrolases
- Neuronal Plasticity
- Neurology & Neurosurgery
- Nerve Degeneration
Citation
APA
Chicago
ICMJE
MLA
NLM
Peng, Y. W., Hao, Y., Petters, R. M., & Wong, F. (2000). Ectopic synaptogenesis in the mammalian retina caused by rod photoreceptor-specific mutations. Nat Neurosci, 3(11), 1121–1127. https://doi.org/10.1038/80639
Peng, Y. W., Y. Hao, R. M. Petters, and F. Wong. “Ectopic synaptogenesis in the mammalian retina caused by rod photoreceptor-specific mutations.” Nat Neurosci 3, no. 11 (November 2000): 1121–27. https://doi.org/10.1038/80639.
Peng YW, Hao Y, Petters RM, Wong F. Ectopic synaptogenesis in the mammalian retina caused by rod photoreceptor-specific mutations. Nat Neurosci. 2000 Nov;3(11):1121–7.
Peng, Y. W., et al. “Ectopic synaptogenesis in the mammalian retina caused by rod photoreceptor-specific mutations.” Nat Neurosci, vol. 3, no. 11, Nov. 2000, pp. 1121–27. Pubmed, doi:10.1038/80639.
Peng YW, Hao Y, Petters RM, Wong F. Ectopic synaptogenesis in the mammalian retina caused by rod photoreceptor-specific mutations. Nat Neurosci. 2000 Nov;3(11):1121–1127.
Published In
Nat Neurosci
DOI
ISSN
1097-6256
Publication Date
November 2000
Volume
3
Issue
11
Start / End Page
1121 / 1127
Location
United States
Related Subject Headings
- Synapses
- Swine
- Rhodopsin
- Retinal Rod Photoreceptor Cells
- Retinal Cone Photoreceptor Cells
- Retina
- Phosphoric Diester Hydrolases
- Neuronal Plasticity
- Neurology & Neurosurgery
- Nerve Degeneration