An immunopathologic study of retinoblastoma protein.

Journal Article (Journal Article)

We investigated the immunoreactivity of the retinoblastoma protein in eight retinoblastoma tumors of different stages of differentiation. All undifferentiated tumor cells failed to show immunoreactivity. In one patient, who had a family history of retinoblastoma and had been treated by radiation, the tumor had a large area of undifferentiated cells and small independent retinocytomas. The tumor cells in the retinocytoma and the cone cells in the adjacent retina, but not the undifferentiated tumor cells, showed positive staining with two anti-Rb antibodies. The immunoreactivity may be related to radiation or differentiation of retinoblastoma and cone cells.

Full Text

Duke Authors

Cited Authors

  • Sawaguchi, S; Peng, Y; Wong, F; Tso, MO

Published Date

  • 1990

Published In

Volume / Issue

  • 88 /

Start / End Page

  • 51 - 61

PubMed ID

  • 2095032

Pubmed Central ID

  • PMC1298577

International Standard Serial Number (ISSN)

  • 0065-9533

Language

  • eng

Conference Location

  • United States