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Molecular basis of an inherited retinal defect in Drosophila.

Publication ,  Journal Article
Wong, F; Hokanson, KM; Chang, LT
Published in: Invest Ophthalmol Vis Sci
February 1985

Fruitflies carrying the autosomal recessive mutation transient receptor potential (trp) are blind in bright light because the receptor potential of such a mutant decays almost completely during an intense stimulus. The trp gene has been localized and a set of partially overlapping genomic clones that include the trp gene has been isolated. The stretch of DNA represented by these genomic clones is found to contain genes that encode for four RNA species. Two of these RNA species are missing in the mutant. This observation is consistent with the notion that the mutation alters the DNA sequence in a region containing signals necessary for the expression of the gene. Accordingly, the molecular basis of the mutant phenotype may be due to the lack of a protein(s) that is/are important for normal visual transduction.

Duke Scholars

Published In

Invest Ophthalmol Vis Sci

ISSN

0146-0404

Publication Date

February 1985

Volume

26

Issue

2

Start / End Page

243 / 246

Location

United States

Related Subject Headings

  • Ultraviolet Rays
  • Retinal Diseases
  • RNA
  • Ophthalmology & Optometry
  • Nucleic Acid Hybridization
  • Mutation
  • Light
  • Electrophoresis, Agar Gel
  • Drosophila
  • Collodion
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wong, F., Hokanson, K. M., & Chang, L. T. (1985). Molecular basis of an inherited retinal defect in Drosophila. Invest Ophthalmol Vis Sci, 26(2), 243–246.
Wong, F., K. M. Hokanson, and L. T. Chang. “Molecular basis of an inherited retinal defect in Drosophila.Invest Ophthalmol Vis Sci 26, no. 2 (February 1985): 243–46.
Wong F, Hokanson KM, Chang LT. Molecular basis of an inherited retinal defect in Drosophila. Invest Ophthalmol Vis Sci. 1985 Feb;26(2):243–6.
Wong, F., et al. “Molecular basis of an inherited retinal defect in Drosophila.Invest Ophthalmol Vis Sci, vol. 26, no. 2, Feb. 1985, pp. 243–46.
Wong F, Hokanson KM, Chang LT. Molecular basis of an inherited retinal defect in Drosophila. Invest Ophthalmol Vis Sci. 1985 Feb;26(2):243–246.

Published In

Invest Ophthalmol Vis Sci

ISSN

0146-0404

Publication Date

February 1985

Volume

26

Issue

2

Start / End Page

243 / 246

Location

United States

Related Subject Headings

  • Ultraviolet Rays
  • Retinal Diseases
  • RNA
  • Ophthalmology & Optometry
  • Nucleic Acid Hybridization
  • Mutation
  • Light
  • Electrophoresis, Agar Gel
  • Drosophila
  • Collodion