Congenital disorders of glycosylation

Journal Article

Congenital disorders of glycosylation (CDG) are a group of disorders involving a defect in the synthesis of oligosaccharides. Oligosaccharides are fundamental for protein stability and cellular communication and are present in almost every cell in the human body. A defect in the synthesis of oligosaccharides can result in multisystemic effects. Congenital disorders of glycosylation are classified into type I and type II disorders, each with subgroup classifications. All CDGs are autosomal recessive disorders, with CDG type I being the most common. This article will explore both types of CDG, their clinical presentation, diagnosis, and management. Copyright © 2012 by The National Association of Neonatal Nurses..

Full Text

Duke Authors

Cited Authors

  • Woods, AG; Woods, CW; Snow, TM

Published Date

  • 2012

Published In

Volume / Issue

  • 12 / 2

Start / End Page

  • 90 - 95

International Standard Serial Number (ISSN)

  • 1536-0903

Digital Object Identifier (DOI)

  • 10.1097/ANC.0b013e318241cb20