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Leptospirosis as frequent cause of acute febrile illness in southern Sri Lanka.

Publication ,  Journal Article
Reller, ME; Bodinayake, C; Nagahawatte, A; Devasiri, V; Kodikara-Arachichi, W; Strouse, JJ; Flom, JE; Dumler, JS; Woods, CW
Published in: Emerg Infect Dis
September 2011

To determine the proportion of fevers caused by leptospirosis, we obtained serum specimens and epidemiologic and clinical data from patients in Galle, Sri Lanka, March-October 2007. Immunoglobulin M ELISA was performed on paired serum specimens to diagnose acute (seroconversion or 4-fold titer rise) or past (titer without rise) leptospirosis and seroprevalence (acute). We compared (individually) the diagnostic yield of acute-phase specimens and clinical impression with paired specimens for acute leptospirosis. Of 889 patients with paired specimens, 120 had acute leptosoirosis and 241 had past leptospirosis. The sensitivity and specificity of acute-phase serum specimens were 17.5% (95% confidence interval [CI] 11.2%-25.5%) and 69.2% (95% CI 65.5%-72.7%), respectively, and of clinical impression 22.9% (95% CI 15.4%-32.0%) and 91.7% (95% CI 89.2%-93.8%), respectively. For identifying acute leptospirosis, clinical impression is insensitive, and immunoglobulin M results are more insensitive and costly. Rapid, pathogen-based tests for early diagnosis are needed.

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Published In

Emerg Infect Dis

DOI

EISSN

1080-6059

Publication Date

September 2011

Volume

17

Issue

9

Start / End Page

1678 / 1684

Location

United States

Related Subject Headings

  • Zoonoses
  • Young Adult
  • Sri Lanka
  • Serologic Tests
  • Sensitivity and Specificity
  • Prospective Studies
  • Prevalence
  • Middle Aged
  • Microbiology
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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Reller, M. E., Bodinayake, C., Nagahawatte, A., Devasiri, V., Kodikara-Arachichi, W., Strouse, J. J., … Woods, C. W. (2011). Leptospirosis as frequent cause of acute febrile illness in southern Sri Lanka. Emerg Infect Dis, 17(9), 1678–1684. https://doi.org/10.3201/eid1709.100915
Reller, Megan E., Champika Bodinayake, Ajith Nagahawatte, Vasantha Devasiri, Wasantha Kodikara-Arachichi, John J. Strouse, Judith E. Flom, J Stephen Dumler, and Christopher W. Woods. “Leptospirosis as frequent cause of acute febrile illness in southern Sri Lanka.Emerg Infect Dis 17, no. 9 (September 2011): 1678–84. https://doi.org/10.3201/eid1709.100915.
Reller ME, Bodinayake C, Nagahawatte A, Devasiri V, Kodikara-Arachichi W, Strouse JJ, et al. Leptospirosis as frequent cause of acute febrile illness in southern Sri Lanka. Emerg Infect Dis. 2011 Sep;17(9):1678–84.
Reller, Megan E., et al. “Leptospirosis as frequent cause of acute febrile illness in southern Sri Lanka.Emerg Infect Dis, vol. 17, no. 9, Sept. 2011, pp. 1678–84. Pubmed, doi:10.3201/eid1709.100915.
Reller ME, Bodinayake C, Nagahawatte A, Devasiri V, Kodikara-Arachichi W, Strouse JJ, Flom JE, Dumler JS, Woods CW. Leptospirosis as frequent cause of acute febrile illness in southern Sri Lanka. Emerg Infect Dis. 2011 Sep;17(9):1678–1684.

Published In

Emerg Infect Dis

DOI

EISSN

1080-6059

Publication Date

September 2011

Volume

17

Issue

9

Start / End Page

1678 / 1684

Location

United States

Related Subject Headings

  • Zoonoses
  • Young Adult
  • Sri Lanka
  • Serologic Tests
  • Sensitivity and Specificity
  • Prospective Studies
  • Prevalence
  • Middle Aged
  • Microbiology
  • Male