Hemophagocytic lymphohistiocytosis in the premature neonate: A case study

Journal Article

Hemophagocytic lymphohistiocytosis (HLH) is a rare disease resulting from an abnormal proliferation of histiocytes within the body's tissues leading to an ineffective immune response. Typically, HLH is characterized by fever, hepatosplenomegaly, cytopenia, hypertriglyceridemia, hypofibrinogenemia, and hemophagocytosis. However, the premature infant with HLH may present differently making diagnosis of the disease cumbersome. If an infant is born with ascites, cytopenias, hypofibrinogenemia, and hepatosplenomegaly, a diagnosis of HLH cannot be ruled out. In addition, premature infants oftentimes will not present with fever because they are kept normothermic from ambient sources. Reports of premature infants with HLH in the literature are rare. This is a case presentation of a 27-week-gestation female with a family history of HLH. Copyright © 2009 by the National Association of Neonatal Nurses.

Full Text

Duke Authors

Cited Authors

  • Woods, AG; Woods, CW

Published Date

  • 2009

Published In

Volume / Issue

  • 9 / 6

Start / End Page

  • 274 - 278

International Standard Serial Number (ISSN)

  • 1536-0903

Digital Object Identifier (DOI)

  • 10.1097/ANC.0b013e3181c1fff7