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Rapid evolution of cis-regulatory sequences via local point mutations.

Publication ,  Journal Article
Stone, JR; Wray, GA
Published in: Molecular biology and evolution
September 2001

Although the evolution of protein-coding sequences within genomes is well understood, the same cannot be said of the cis-regulatory regions that control transcription. Yet, changes in gene expression are likely to constitute an important component of phenotypic evolution. We simulated the evolution of new transcription factor binding sites via local point mutations. The results indicate that new binding sites appear and become fixed within populations on microevolutionary timescales under an assumption of neutral evolution. Even combinations of two new binding sites evolve very quickly. We predict that local point mutations continually generate considerable genetic variation that is capable of altering gene expression.

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Published In

Molecular biology and evolution

DOI

EISSN

1537-1719

ISSN

0737-4038

Publication Date

September 2001

Volume

18

Issue

9

Start / End Page

1764 / 1770

Related Subject Headings

  • Transcription Factors
  • Regulatory Sequences, Nucleic Acid
  • Point Mutation
  • Humans
  • Evolutionary Biology
  • Evolution, Molecular
  • Databases, Factual
  • DNA
  • Computer Simulation
  • Binding Sites
 

Citation

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Stone, J. R., & Wray, G. A. (2001). Rapid evolution of cis-regulatory sequences via local point mutations. Molecular Biology and Evolution, 18(9), 1764–1770. https://doi.org/10.1093/oxfordjournals.molbev.a003964
Stone, J. R., and G. A. Wray. “Rapid evolution of cis-regulatory sequences via local point mutations.Molecular Biology and Evolution 18, no. 9 (September 2001): 1764–70. https://doi.org/10.1093/oxfordjournals.molbev.a003964.
Stone JR, Wray GA. Rapid evolution of cis-regulatory sequences via local point mutations. Molecular biology and evolution. 2001 Sep;18(9):1764–70.
Stone, J. R., and G. A. Wray. “Rapid evolution of cis-regulatory sequences via local point mutations.Molecular Biology and Evolution, vol. 18, no. 9, Sept. 2001, pp. 1764–70. Epmc, doi:10.1093/oxfordjournals.molbev.a003964.
Stone JR, Wray GA. Rapid evolution of cis-regulatory sequences via local point mutations. Molecular biology and evolution. 2001 Sep;18(9):1764–1770.
Journal cover image

Published In

Molecular biology and evolution

DOI

EISSN

1537-1719

ISSN

0737-4038

Publication Date

September 2001

Volume

18

Issue

9

Start / End Page

1764 / 1770

Related Subject Headings

  • Transcription Factors
  • Regulatory Sequences, Nucleic Acid
  • Point Mutation
  • Humans
  • Evolutionary Biology
  • Evolution, Molecular
  • Databases, Factual
  • DNA
  • Computer Simulation
  • Binding Sites