3-D deformation guided on-line modification of multi-leaf collimators for adaptive radiation therapy


Journal Article

Adaptive radiation therapy (ART) requires an on-line modification of the treatment plan to compensate for the motion of organs. In this paper, an improved multi-leaf collimator (MLC) deformation approach is proposed to accurately compensate for the organ motion between the planning and treatment scans for ART. Instead of using slice-by-slice 2-D deformation field as in the original MLC deformation method, 3-D deformation field is first recovered by a volumetric deformable registration method to guide the MLC modification. In order to minimize the toxicity on organ-at-risk (OAR), the deformation fields of the OAR and planning target volume (PTV) are jointly used to adjust the MLC sequence of the original plan. The proposed approach has been applied to the radiotherapy for prostate cancer. Preliminary experimental results have demonstrated that the proposed method outperformed the original MLC approach with much reduced toxicity on OAR while maintaining great radiation efficacy on PTV. © 2008 Springer-Verlag Berlin Heidelberg.

Full Text

Duke Authors

Cited Authors

  • Zhou, B; Xuan, J; Wu, Q; Wang, Y

Published Date

  • July 28, 2008

Published In

Volume / Issue

  • 5112 LNCS /

Start / End Page

  • 798 - 806

Electronic International Standard Serial Number (EISSN)

  • 1611-3349

International Standard Serial Number (ISSN)

  • 0302-9743

Digital Object Identifier (DOI)

  • 10.1007/978-3-540-69812-8_79

Citation Source

  • Scopus