Control of the postmating behavioral switch in Drosophila females by internal sensory neurons.

Journal Article (Journal Article)

Mating induces changes in the receptivity and egg-laying behavior in Drosophila females, primarily due to a peptide pheromone called sex peptide which is transferred with the sperm into the female reproductive tract during copulation. Whereas sex peptide is generally believed to modulate fruitless-GAL4-expressing neurons in the central nervous system to produce behavioral changes, we found that six to eight sensory neurons on the reproductive tract labeled by both ppk-GAL4 and fruitless-GAL4 can sense sex peptide to control the induction of postmating behaviors. In these sensory neurons, sex peptide appears to act through Pertussis toxin-sensitive G proteins and suppression of protein kinase A activity to reduce synaptic output. Our results uncover a neuronal mechanism by which sex peptide exerts its control over reproductive behaviors in Drosophila females.

Full Text

Duke Authors

Cited Authors

  • Yang, C-H; Rumpf, S; Xiang, Y; Gordon, MD; Song, W; Jan, LY; Jan, Y-N

Published Date

  • February 26, 2009

Published In

Volume / Issue

  • 61 / 4

Start / End Page

  • 519 - 526

PubMed ID

  • 19249273

Pubmed Central ID

  • PMC2748846

Electronic International Standard Serial Number (EISSN)

  • 1097-4199

Digital Object Identifier (DOI)

  • 10.1016/j.neuron.2008.12.021


  • eng

Conference Location

  • United States