A replication-defective human adenovirus recombinant serves as a highly efficacious vaccine carrier.


Journal Article

In this manuscript, an E1 and E3 deleted adenoviral recombinant expressing the rabies virus glycoprotein (G protein) under the control of the cytomegalovirus early promoter was tested for induction of a rabies virus-specific immune response in mice. The construct was found to induce neutralizing antibodies and cytolytic T cells to rabies virus. Mice vaccinated with the adenoviral construct either by the systemic route or by application into the airways were protected against a subsequent infection with a virulent strain of rabies virus. The efficacy of the replication-defective construct was far superior to that of a well-characterized vaccinia rabies glycoprotein recombinant.

Full Text

Cited Authors

  • Xiang, ZQ; Yang, Y; Wilson, JM; Ertl, HC

Published Date

  • May 1996

Published In

Volume / Issue

  • 219 / 1

Start / End Page

  • 220 - 227

PubMed ID

  • 8623532

Pubmed Central ID

  • 8623532

Electronic International Standard Serial Number (EISSN)

  • 1096-0341

International Standard Serial Number (ISSN)

  • 0042-6822

Digital Object Identifier (DOI)

  • 10.1006/viro.1996.0239


  • eng