Lysine modifications and autophagy.

Published

Journal Article (Review)

Nutrient deprivation or cellular stress leads to the activation of a catabolic pathway that is conserved across species, known as autophagy. This process is considered to be adaptive and plays an important role in a number of cellular processes, including metabolism, immunity and development. Autophagy has also been linked to diseases, such as cancer and neurodegeneration, highlighting the importance of a better insight into its regulation. In the present chapter, we discuss how PTMs (post-translational modifications) of lysine residues by acetylation and ubiquitination alter the function of key proteins involved in the activation, maturation and substrate selectivity of autophagy. We also discuss the clinical potential of targeting these modifications to modulate autophagic activities.

Full Text

Duke Authors

Cited Authors

  • Norris, KL; Yao, T-P

Published Date

  • 2012

Published In

Volume / Issue

  • 52 /

Start / End Page

  • 65 - 77

PubMed ID

  • 22708564

Pubmed Central ID

  • 22708564

Electronic International Standard Serial Number (EISSN)

  • 1744-1358

Digital Object Identifier (DOI)

  • 10.1042/bse0520065

Language

  • eng

Conference Location

  • England