Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP.

Published

Journal Article

Mice with monoallelic inactivation of the CBP gene develop highly penetrant, multilineage defects in hematopoietic differentiation and, with advancing age, an increased incidence of hematologic malignancies. The latter are characterized, at least in some cases, by loss of heterozygosity (LOH) at the CBP locus. No such pathology was observed in wild-type or p300 heterozygous null mice of the same age and genetic background. Thus, a full complement of CBP, but not p300, is required for normal hematopoietic differentiation. These results also provide the first experimental evidence for the hypothesis that CBP has tumor-suppressing activity.

Full Text

Duke Authors

Cited Authors

  • Kung, AL; Rebel, VI; Bronson, RT; Ch'ng, LE; Sieff, CA; Livingston, DM; Yao, TP

Published Date

  • February 1, 2000

Published In

Volume / Issue

  • 14 / 3

Start / End Page

  • 272 - 277

PubMed ID

  • 10673499

Pubmed Central ID

  • 10673499

International Standard Serial Number (ISSN)

  • 0890-9369

Language

  • eng

Conference Location

  • United States