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A stimulus-specific role for CREB-binding protein (CBP) in T cell receptor-activated tumor necrosis factor alpha gene expression.

Publication ,  Journal Article
Falvo, JV; Brinkman, BM; Tsytsykova, AV; Tsai, EY; Yao, TP; Kung, AL; Goldfeld, AE
Published in: Proc Natl Acad Sci U S A
April 11, 2000

The cAMP response element binding protein (CREB)-binding protein (CBP)/p300 family of coactivator proteins regulates gene transcription through the integration of multiple signal transduction pathways. Here, we show that induction of tumor necrosis factor alpha (TNF-alpha) gene expression in T cells stimulated by engagement of the T cell receptor (TCR) or by virus infection requires CBP/p300. Strikingly, in mice lacking one copy of the CBP gene, TNF-alpha gene induction by TCR activation is inhibited, whereas virus induction of the TNF-alpha gene is not affected. Consistent with these findings, the transcriptional activity of CBP is strongly potentiated by TCR activation but not by virus infection of T cells. Thus, CBP gene dosage and transcriptional activity are critical in TCR-dependent TNF-alpha gene expression, demonstrating a stimulus-specific requirement for CBP in the regulation of a specific gene.

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Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

April 11, 2000

Volume

97

Issue

8

Start / End Page

3925 / 3929

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Transcriptional Activation
  • Transcription Factors
  • Trans-Activators
  • Receptors, Antigen, T-Cell
  • Promoter Regions, Genetic
  • Nuclear Proteins
  • NFATC Transcription Factors
  • Mice
  • Humans
 

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Falvo, J. V., Brinkman, B. M., Tsytsykova, A. V., Tsai, E. Y., Yao, T. P., Kung, A. L., & Goldfeld, A. E. (2000). A stimulus-specific role for CREB-binding protein (CBP) in T cell receptor-activated tumor necrosis factor alpha gene expression. Proc Natl Acad Sci U S A, 97(8), 3925–3929. https://doi.org/10.1073/pnas.97.8.3925
Falvo, J. V., B. M. Brinkman, A. V. Tsytsykova, E. Y. Tsai, T. P. Yao, A. L. Kung, and A. E. Goldfeld. “A stimulus-specific role for CREB-binding protein (CBP) in T cell receptor-activated tumor necrosis factor alpha gene expression.Proc Natl Acad Sci U S A 97, no. 8 (April 11, 2000): 3925–29. https://doi.org/10.1073/pnas.97.8.3925.
Falvo JV, Brinkman BM, Tsytsykova AV, Tsai EY, Yao TP, Kung AL, et al. A stimulus-specific role for CREB-binding protein (CBP) in T cell receptor-activated tumor necrosis factor alpha gene expression. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):3925–9.
Falvo, J. V., et al. “A stimulus-specific role for CREB-binding protein (CBP) in T cell receptor-activated tumor necrosis factor alpha gene expression.Proc Natl Acad Sci U S A, vol. 97, no. 8, Apr. 2000, pp. 3925–29. Pubmed, doi:10.1073/pnas.97.8.3925.
Falvo JV, Brinkman BM, Tsytsykova AV, Tsai EY, Yao TP, Kung AL, Goldfeld AE. A stimulus-specific role for CREB-binding protein (CBP) in T cell receptor-activated tumor necrosis factor alpha gene expression. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):3925–3929.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

April 11, 2000

Volume

97

Issue

8

Start / End Page

3925 / 3929

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Transcriptional Activation
  • Transcription Factors
  • Trans-Activators
  • Receptors, Antigen, T-Cell
  • Promoter Regions, Genetic
  • Nuclear Proteins
  • NFATC Transcription Factors
  • Mice
  • Humans