The nuclear hormone receptor coactivator SRC-1 is a specific target of p300.
Journal Article
p300 and its family member, CREB-binding protein (CBP), function as key transcriptional coactivators by virtue of their interaction with the activated forms of certain transcription factors. In a search for additional cellular targets of p300/CBP, a protein-protein cloning strategy, surprisingly identified SRC-1, a coactivator involved in nuclear hormone receptor transcriptional activity, as a p300/CBP interactive protein. p300 and SRC-1 interact, specifically, in vitro and they also form complexes in vivo. Moreover, we show that SRC-1 encodes a new member of the basic helix-loop-helix-PAS domain family and that it physically interacts with the retinoic acid receptor in response to hormone binding. Together, these results implicate p300 as a component of the retinoic acid signaling pathway, operating, in part, through specific interaction with a nuclear hormone receptor coactivator, SRC-1.
Full Text
Duke Authors
Cited Authors
- Yao, TP; Ku, G; Zhou, N; Scully, R; Livingston, DM
Published Date
- October 1, 1996
Published In
Volume / Issue
- 93 / 20
Start / End Page
- 10626 - 10631
PubMed ID
- 8855229
Pubmed Central ID
- 8855229
International Standard Serial Number (ISSN)
- 0027-8424
Digital Object Identifier (DOI)
- 10.1073/pnas.93.20.10626
Language
- eng
Conference Location
- United States