The nuclear hormone receptor coactivator SRC-1 is a specific target of p300.

Journal Article (Journal Article)

p300 and its family member, CREB-binding protein (CBP), function as key transcriptional coactivators by virtue of their interaction with the activated forms of certain transcription factors. In a search for additional cellular targets of p300/CBP, a protein-protein cloning strategy, surprisingly identified SRC-1, a coactivator involved in nuclear hormone receptor transcriptional activity, as a p300/CBP interactive protein. p300 and SRC-1 interact, specifically, in vitro and they also form complexes in vivo. Moreover, we show that SRC-1 encodes a new member of the basic helix-loop-helix-PAS domain family and that it physically interacts with the retinoic acid receptor in response to hormone binding. Together, these results implicate p300 as a component of the retinoic acid signaling pathway, operating, in part, through specific interaction with a nuclear hormone receptor coactivator, SRC-1.

Full Text

Duke Authors

Cited Authors

  • Yao, TP; Ku, G; Zhou, N; Scully, R; Livingston, DM

Published Date

  • October 1, 1996

Published In

Volume / Issue

  • 93 / 20

Start / End Page

  • 10626 - 10631

PubMed ID

  • 8855229

Pubmed Central ID

  • PMC38204

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.93.20.10626


  • eng

Conference Location

  • United States