Alternative translation initiation site usage results in two structurally distinct forms of Pit-1.

Journal Article (Journal Article)

Pit-1 is a pituitary-specific transcription factor that plays a critical role in the normal development of the anterior pituitary gland. Previous analyses have shown that this protein exists in the rat pituitary gland and in rat pituitary-derived cell lines as two forms of relative molecular mass 33 and 31 kDa. This aspect of Pit-1 expression has been conserved throughout the evolution from rodents to humans. Here, we determine the origin of these structurally distinct forms of Pit-1 protein and find that these arise as a consequence of the alternative usage of translation initiation sites present in Pit-1 mRNA.

Full Text

Duke Authors

Cited Authors

  • Voss, JW; Yao, TP; Rosenfeld, MG

Published Date

  • July 15, 1991

Published In

Volume / Issue

  • 266 / 20

Start / End Page

  • 12832 - 12835

PubMed ID

  • 2071572

International Standard Serial Number (ISSN)

  • 0021-9258


  • eng

Conference Location

  • United States