Alternative translation initiation site usage results in two structurally distinct forms of Pit-1.
Published
Journal Article
Pit-1 is a pituitary-specific transcription factor that plays a critical role in the normal development of the anterior pituitary gland. Previous analyses have shown that this protein exists in the rat pituitary gland and in rat pituitary-derived cell lines as two forms of relative molecular mass 33 and 31 kDa. This aspect of Pit-1 expression has been conserved throughout the evolution from rodents to humans. Here, we determine the origin of these structurally distinct forms of Pit-1 protein and find that these arise as a consequence of the alternative usage of translation initiation sites present in Pit-1 mRNA.
Full Text
Duke Authors
Cited Authors
- Voss, JW; Yao, TP; Rosenfeld, MG
Published Date
- July 15, 1991
Published In
Volume / Issue
- 266 / 20
Start / End Page
- 12832 - 12835
PubMed ID
- 2071572
Pubmed Central ID
- 2071572
International Standard Serial Number (ISSN)
- 0021-9258
Language
- eng
Conference Location
- United States