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Leukocyte telomere length, breast cancer risk in the offspring: the relations with father's age at birth.

Publication ,  Journal Article
Arbeev, KG; Hunt, SC; Kimura, M; Aviv, A; Yashin, AI
Published in: Mechanisms of ageing and development
April 2011

Recent studies have reported that leukocyte telomere length (LTL) is longer in offspring of older fathers. Longer telomeres might increase cancer risk. We examined the relation of father's age at the birth of the offspring (FAB) with LTL in the offspring in 2177 participants of the Family Heart Study and the probability of developing breast cancer in 1405 women from the Framingham Heart Study (offspring cohort). For each year of increase in FAB (adjusted for mother's age at birth), LTLs in the daughters and sons were longer by 19.4bp and 12.2bp, respectively (p<0.0001). Daughters of older fathers were less likely to stay free of breast cancer compared to daughters of younger fathers in empirical (p=0.014) and Cox regression analyses (p=0.0012) adjusted for relevant covariates. We conclude that older fathers endow their offspring with a longer LTL and their daughters with increased susceptibility to breast cancer. These independent observations cannot provide evidence for a causal relationship, mediated by telomere length, between FAB and increased breast cancer risk in daughters. However, with couples delaying having children in today's society, studies exploring the LTL association with increased breast cancer risk in daughters of older fathers might be timely and relevant.

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Published In

Mechanisms of ageing and development

DOI

EISSN

1872-6216

ISSN

0047-6374

Publication Date

April 2011

Volume

132

Issue

4

Start / End Page

149 / 153

Related Subject Headings

  • Telomere
  • Risk
  • Proportional Hazards Models
  • Paternal Age
  • Middle Aged
  • Male
  • Leukocytes
  • Humans
  • Gerontology
  • Genetic Predisposition to Disease
 

Citation

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ICMJE
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Arbeev, K. G., Hunt, S. C., Kimura, M., Aviv, A., & Yashin, A. I. (2011). Leukocyte telomere length, breast cancer risk in the offspring: the relations with father's age at birth. Mechanisms of Ageing and Development, 132(4), 149–153. https://doi.org/10.1016/j.mad.2011.02.004
Arbeev, Konstantin G., Steven C. Hunt, Masayuki Kimura, Abraham Aviv, and Anatoliy I. Yashin. “Leukocyte telomere length, breast cancer risk in the offspring: the relations with father's age at birth.Mechanisms of Ageing and Development 132, no. 4 (April 2011): 149–53. https://doi.org/10.1016/j.mad.2011.02.004.
Arbeev KG, Hunt SC, Kimura M, Aviv A, Yashin AI. Leukocyte telomere length, breast cancer risk in the offspring: the relations with father's age at birth. Mechanisms of ageing and development. 2011 Apr;132(4):149–53.
Arbeev, Konstantin G., et al. “Leukocyte telomere length, breast cancer risk in the offspring: the relations with father's age at birth.Mechanisms of Ageing and Development, vol. 132, no. 4, Apr. 2011, pp. 149–53. Epmc, doi:10.1016/j.mad.2011.02.004.
Arbeev KG, Hunt SC, Kimura M, Aviv A, Yashin AI. Leukocyte telomere length, breast cancer risk in the offspring: the relations with father's age at birth. Mechanisms of ageing and development. 2011 Apr;132(4):149–153.
Journal cover image

Published In

Mechanisms of ageing and development

DOI

EISSN

1872-6216

ISSN

0047-6374

Publication Date

April 2011

Volume

132

Issue

4

Start / End Page

149 / 153

Related Subject Headings

  • Telomere
  • Risk
  • Proportional Hazards Models
  • Paternal Age
  • Middle Aged
  • Male
  • Leukocytes
  • Humans
  • Gerontology
  • Genetic Predisposition to Disease