Age trajectories of physiological indices in relation to healthy life course.

Journal Article (Journal Article)

We analysed relationship between the risk of onset of "unhealthy life" (defined as the onset of cancer, cardiovascular diseases, or diabetes) and longitudinal changes in body mass index, diastolic blood pressure, hematocrit, pulse pressure, pulse rate, and serum cholesterol in the Framingham Heart Study (Original Cohort) using the stochastic process model of human mortality and aging. The analyses demonstrate how decline in resistance to stresses and adaptive capacity accompanying human aging can be evaluated from longitudinal data. We showed how these components of the aging process, as well as deviation of the trajectories of physiological indices from those minimising the risk at respective ages, can lead to an increase in the risk of onset of unhealthy life with age. The results indicate the presence of substantial gender difference in aging related decline in stress resistance and adaptive capacity, which can contribute to differences in the shape of the sex-specific patterns of incidence rates of aging related diseases.

Full Text

Duke Authors

Cited Authors

  • Arbeev, KG; Ukraintseva, SV; Akushevich, I; Kulminski, AM; Arbeeva, LS; Akushevich, L; Culminskaya, IV; Yashin, AI

Published Date

  • March 2011

Published In

Volume / Issue

  • 132 / 3

Start / End Page

  • 93 - 102

PubMed ID

  • 21262255

Pubmed Central ID

  • PMC3064744

Electronic International Standard Serial Number (EISSN)

  • 1872-6216

International Standard Serial Number (ISSN)

  • 0047-6374

Digital Object Identifier (DOI)

  • 10.1016/j.mad.2011.01.001


  • eng