Health and function of participants in the Long Life Family Study: A comparison with other cohorts.

Published

Journal Article

Individuals from families recruited for the Long Life Family Study (LLFS) (n= 4559) were examined and compared to individuals from other cohorts to determine whether the recruitment targeting longevity resulted in a cohort of individuals with better health and function. Other cohorts with similar data included the Cardiovascular Health Study, the Framingham Heart Study, and the New England Centenarian Study. Diabetes, chronic pulmonary disease and peripheral artery disease tended to be less common in LLFS probands and offspring compared to similar aged persons in the other cohorts. Pulse pressure and triglycerides were lower, high density lipids were higher, and a perceptual speed task and gait speed were better in LLFS. Age-specific comparisons showed differences that would be consistent with a higher peak, later onset of decline or slower rate of change across age in LLFS participants. These findings suggest several priority phenotypes for inclusion in future genetic analysis to identify loci contributing to exceptional survival.

Full Text

Duke Authors

Cited Authors

  • Newman, AB; Glynn, NW; Taylor, CA; Sebastiani, P; Perls, TT; Mayeux, R; Christensen, K; Zmuda, JM; Barral, S; Lee, JH; Simonsick, EM; Walston, JD; Yashin, AI; Hadley, E

Published Date

  • January 2011

Published In

Volume / Issue

  • 3 / 1

Start / End Page

  • 63 - 76

PubMed ID

  • 21258136

Pubmed Central ID

  • 21258136

Electronic International Standard Serial Number (EISSN)

  • 1945-4589

International Standard Serial Number (ISSN)

  • 1945-4589

Digital Object Identifier (DOI)

  • 10.18632/aging.100242

Language

  • eng