Early hematopoietic effects of chronic radiation exposure in humans.

Journal Article

The major goal of this study is to investigate and quantitatively describe the nature of the relationship between the characteristics of chronic exposure to ionizing radiation and specific patterns of hematopoiesis reduction. The study is based on about 3,200 hemograms taken for inhabitants of the Techa riverside villages over the years 1951-1956, i.e., the period characterized by a gradual decrease in dose rates. The mean cumulative red bone marrow dose was 333.6 + or - 4.6 mGy. The approach to statistical analyses involved both empirical methods and modeling (generalized linear models and logistic regressions). The results of the analyses highlighted a gradual increase in the frequency of cytopenias with dose rate. The impact of exposure on hematopoiesis reduction patterns was found to be more substantial than that of age and health status. Dose rates resulting in a two-fold increase in the frequency of cytopenias have been estimated.

Full Text

Duke Authors

Cited Authors

  • Akleyev, AV; Akushevich, IV; Dimov, GP; Veremeyeva, GA; Varfolomeyeva, TA; Ukraintseva, SV; Yashin, AI

Published Date

  • September 2010

Published In

Volume / Issue

  • 99 / 3

Start / End Page

  • 330 - 336

PubMed ID

  • 20699694

Electronic International Standard Serial Number (EISSN)

  • 1538-5159

International Standard Serial Number (ISSN)

  • 0017-9078

Digital Object Identifier (DOI)

  • 10.1097/hp.0b013e3181c2f315

Language

  • eng