Multiple mild heat-shocks decrease the Gompertz component of mortality in Caenorhabditis elegans.
Exposure to mild heat-stress (heat-shock) can significantly increase the life expectancy of the nematode Caenorhabditis elegans. A single heat-shock early in life extends longevity by 20% or more and affects life-long mortality by decreasing initial mortality only; the rate of increase in subsequent mortality (Gompertz component) is unchanged. Repeated mild heat-shocks throughout life have a larger effect on life span than does a single heat-shock early in life. Here, we ask how multiple heat-shocks affect the mortality trajectory in nematodes and find increases of life expectancy of close to 50% and of maximum longevity as well. We examined mortality using large numbers of animals and found that multiple heat-shocks not only decrease initial mortality, but also slow the Gompertz rate of increase in mortality. Thus, multiple heat-shocks have anti-aging hormetic effects and represent an effective approach for modulating aging.
Duke Scholars
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Related Subject Headings
- Survival Analysis
- Stress, Physiological
- Longevity
- Hot Temperature
- Heat-Shock Response
- Heat-Shock Proteins
- Gerontology
- Caenorhabditis elegans
- Animals
- Aging
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Survival Analysis
- Stress, Physiological
- Longevity
- Hot Temperature
- Heat-Shock Response
- Heat-Shock Proteins
- Gerontology
- Caenorhabditis elegans
- Animals
- Aging