Multiple mild heat-shocks decrease the Gompertz component of mortality in Caenorhabditis elegans.

Published

Journal Article

Exposure to mild heat-stress (heat-shock) can significantly increase the life expectancy of the nematode Caenorhabditis elegans. A single heat-shock early in life extends longevity by 20% or more and affects life-long mortality by decreasing initial mortality only; the rate of increase in subsequent mortality (Gompertz component) is unchanged. Repeated mild heat-shocks throughout life have a larger effect on life span than does a single heat-shock early in life. Here, we ask how multiple heat-shocks affect the mortality trajectory in nematodes and find increases of life expectancy of close to 50% and of maximum longevity as well. We examined mortality using large numbers of animals and found that multiple heat-shocks not only decrease initial mortality, but also slow the Gompertz rate of increase in mortality. Thus, multiple heat-shocks have anti-aging hormetic effects and represent an effective approach for modulating aging.

Full Text

Duke Authors

Cited Authors

  • Wu, D; Cypser, JR; Yashin, AI; Johnson, TE

Published Date

  • September 2009

Published In

Volume / Issue

  • 44 / 9

Start / End Page

  • 607 - 612

PubMed ID

  • 19580861

Pubmed Central ID

  • 19580861

Electronic International Standard Serial Number (EISSN)

  • 1873-6815

International Standard Serial Number (ISSN)

  • 0531-5565

Digital Object Identifier (DOI)

  • 10.1016/j.exger.2009.06.007

Language

  • eng