Health-related phenotypes and longevity in danish twins.

Journal Article

Aging studies can be facilitated by refocusing from longevity phenotypes to their proxies (intermediate phenotypes). Robust selection of the intermediate phenotypes requires data on such phenotypes and life span measured in the same individuals, which is not always the case in aging studies. A promising approach is to select intermediate phenotypes using information on longevity measured in related individuals. We evaluated feasibility of this approach focusing on 32 geriatric diseases as potential intermediate phenotypes of longevity assessed in the Longitudinal Study of Aging Danish Twins. Our analyses reveal that geriatric diseases measured in some family members can predict life span in the other family members both individually and cumulatively ensuring that this approach for selection of intermediate phenotypes is feasible. The cumulative-trait approach is more promising for such studies compared with the individual-trait approach. Heritable health dimensions contributing to a decrease of life span have sex-insensitive and sex-specific components.

Full Text

Duke Authors

Cited Authors

  • Kulminski, AM; Arbeev, KG; Culminskaya, IV; Ukraintseva, SV; Christensen, K; Yashin, AI

Published Date

  • January 2009

Published In

Volume / Issue

  • 64 / 1

Start / End Page

  • 1 - 8

PubMed ID

  • 19211549

Pubmed Central ID

  • 19211549

Electronic International Standard Serial Number (EISSN)

  • 1758-535X

International Standard Serial Number (ISSN)

  • 1079-5006

Digital Object Identifier (DOI)

  • 10.1093/gerona/gln051


  • eng