Trade-off between cancer and aging: what role do other diseases play? Evidence from experimental and human population studies.

Journal Article (Journal Article)

The potential gain in life expectancy which could result from the complete elimination of mortality from cancer in the U.S. would not exceed 3 years if one were to consider cancer independently of other causes of death. In this paper, we review evidence of trade-offs between cancer and aging as well as between cancer and other diseases, which, if taken into account, may substantially increase estimates of gain in life expectancy resulting from cancer eradication. We also used the Multiple Causes of Death (MCD) data to evaluate correlations among mortalities from cancer and other major disorders including heart disease, stroke, diabetes, Alzheimer's, Parkinson's diseases, and asthma. Our analyses revealed significant negative correlations between cancer and other diseases suggesting stronger population effects of cancer eradication. Possible mechanisms of the observed dependencies and emerging perspectives of using dependent competing risks models for evaluating the effects of reduction of mortality from cancer on life expectancy are discussed.

Full Text

Duke Authors

Cited Authors

  • Yashin, AI; Ukraintseva, SV; Akushevich, IV; Arbeev, KG; Kulminski, A; Akushevich, L

Published Date

  • January 2009

Published In

Volume / Issue

  • 130 / 1-2

Start / End Page

  • 98 - 104

PubMed ID

  • 18452970

Pubmed Central ID

  • PMC2708086

Electronic International Standard Serial Number (EISSN)

  • 1872-6216

International Standard Serial Number (ISSN)

  • 0047-6374

Digital Object Identifier (DOI)

  • 10.1016/j.mad.2008.03.006


  • eng