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A correlated frailty model with long-term survivors for estimating the heritability of breast cancer.

Publication ,  Journal Article
Locatelli, I; Rosina, A; Lichtenstein, P; Yashin, AI
Published in: Statistics in medicine
September 2007

The aim of this study is to investigate the role of genetics and environment in susceptibility to breast cancer (frailty). An interdisciplinary approach was adopted, combining a correlated frailty-mixture model with genetic equations, allowing for decomposition of the frailty variance into genetic and environmental components. In addition, the possibility that a fraction of the population under study is 'immune' to the disease is evaluated, and changes in heritability estimates introducing a fraction of non-susceptible individuals are determined. The methodology is applied to breast cancer data from the Swedish Twin Registry, including information about all female monozygotic and dizygotic twin pairs born in Sweden between 1886 and 1967. The inferential problem is solved in a Bayesian framework and the numerical work is carried out using Markov chain Monte Carlo (MCMC) methods.

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Published In

Statistics in medicine

DOI

EISSN

1097-0258

ISSN

0277-6715

Publication Date

September 2007

Volume

26

Issue

20

Start / End Page

3722 / 3734

Related Subject Headings

  • Twin Studies as Topic
  • Sweden
  • Survivors
  • Statistics & Probability
  • Registries
  • Models, Statistical
  • Humans
  • Female
  • Environmental Exposure
  • Diseases in Twins
 

Citation

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Locatelli, I., Rosina, A., Lichtenstein, P., & Yashin, A. I. (2007). A correlated frailty model with long-term survivors for estimating the heritability of breast cancer. Statistics in Medicine, 26(20), 3722–3734. https://doi.org/10.1002/sim.2761
Locatelli, Isabella, Alessandro Rosina, Paul Lichtenstein, and Anatoli I. Yashin. “A correlated frailty model with long-term survivors for estimating the heritability of breast cancer.Statistics in Medicine 26, no. 20 (September 2007): 3722–34. https://doi.org/10.1002/sim.2761.
Locatelli I, Rosina A, Lichtenstein P, Yashin AI. A correlated frailty model with long-term survivors for estimating the heritability of breast cancer. Statistics in medicine. 2007 Sep;26(20):3722–34.
Locatelli, Isabella, et al. “A correlated frailty model with long-term survivors for estimating the heritability of breast cancer.Statistics in Medicine, vol. 26, no. 20, Sept. 2007, pp. 3722–34. Epmc, doi:10.1002/sim.2761.
Locatelli I, Rosina A, Lichtenstein P, Yashin AI. A correlated frailty model with long-term survivors for estimating the heritability of breast cancer. Statistics in medicine. 2007 Sep;26(20):3722–3734.
Journal cover image

Published In

Statistics in medicine

DOI

EISSN

1097-0258

ISSN

0277-6715

Publication Date

September 2007

Volume

26

Issue

20

Start / End Page

3722 / 3734

Related Subject Headings

  • Twin Studies as Topic
  • Sweden
  • Survivors
  • Statistics & Probability
  • Registries
  • Models, Statistical
  • Humans
  • Female
  • Environmental Exposure
  • Diseases in Twins