A correlated frailty model with long-term survivors for estimating the heritability of breast cancer.

Published

Journal Article

The aim of this study is to investigate the role of genetics and environment in susceptibility to breast cancer (frailty). An interdisciplinary approach was adopted, combining a correlated frailty-mixture model with genetic equations, allowing for decomposition of the frailty variance into genetic and environmental components. In addition, the possibility that a fraction of the population under study is 'immune' to the disease is evaluated, and changes in heritability estimates introducing a fraction of non-susceptible individuals are determined. The methodology is applied to breast cancer data from the Swedish Twin Registry, including information about all female monozygotic and dizygotic twin pairs born in Sweden between 1886 and 1967. The inferential problem is solved in a Bayesian framework and the numerical work is carried out using Markov chain Monte Carlo (MCMC) methods.

Full Text

Duke Authors

Cited Authors

  • Locatelli, I; Rosina, A; Lichtenstein, P; Yashin, AI

Published Date

  • September 2007

Published In

Volume / Issue

  • 26 / 20

Start / End Page

  • 3722 - 3734

PubMed ID

  • 17139701

Pubmed Central ID

  • 17139701

Electronic International Standard Serial Number (EISSN)

  • 1097-0258

International Standard Serial Number (ISSN)

  • 0277-6715

Digital Object Identifier (DOI)

  • 10.1002/sim.2761

Language

  • eng