The accuracy of statistical estimates in genetic studies of aging can be significantly improved.

Journal Article

The sample size of the data used in genetic studies is often a factor limiting the accuracy of statistical estimates. In this paper we suggest a new approach to evaluation of genetic influence on risk of development of aging-related health disorders. The approach results in substantial improvement of the accuracy of statistical estimates without an increase in the size of the genetic sample. The approach is based on the joint analysis of data from the genetic samples and easily accessible non-genetic data, such as data collected in epidemiological, demographic, and longitudinal studies of human aging and aging-related pathologies.

Full Text

Duke Authors

Cited Authors

  • Yashin, AI; Arbeev, KG; Ukraintseva, SV

Published Date

  • June 2007

Published In

Volume / Issue

  • 8 / 3

Start / End Page

  • 243 - 255

PubMed ID

  • 17160500

Pubmed Central ID

  • 17160500

Electronic International Standard Serial Number (EISSN)

  • 1573-6768

International Standard Serial Number (ISSN)

  • 1389-5729

Digital Object Identifier (DOI)

  • 10.1007/s10522-006-9072-4


  • eng