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Insights on aging and exceptional longevity from longitudinal data: novel findings from the Framingham Heart Study.

Publication ,  Journal Article
Yashin, AI; Akushevich, IV; Arbeev, KG; Akushevich, L; Ukraintseva, SV; Kulminski, A
Published in: Age (Dordrecht, Netherlands)
December 2006

Age trajectories of physiological indices contain important information about aging-related changes in the human organism and therefore may help us understand human longevity. The goal of this study is to investigate whether shapes of such trajectories earlier in life affect the residual life span distribution. We used longitudinal limited access data from seven physiological indices and life spans of respective individuals collected in the Framingham Heart Study (FHS). These include: diastolic blood pressure (DBP), pulse pressure (PP), body mass index (BMI), serum cholesterol (SCH), blood glucose (BG), hematocrit (HC), and pulse rate (PR). We developed a method for assigning individuals to groups of potentially long-lived (PLL) and potentially medium-lived (PML) groups using age trajectories of physiological indices at the age interval between 40 and 60 years. The analysis shows that the longevity of individuals who survived to age of 65 depends on the behavior of the physiological indices between 40 and 60 years of age.

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Published In

Age (Dordrecht, Netherlands)

DOI

EISSN

1574-4647

ISSN

0161-9152

Publication Date

December 2006

Volume

28

Issue

4

Start / End Page

363 / 374

Related Subject Headings

  • Gerontology
  • 52 Psychology
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 17 Psychology and Cognitive Sciences
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
 

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Yashin, A. I., Akushevich, I. V., Arbeev, K. G., Akushevich, L., Ukraintseva, S. V., & Kulminski, A. (2006). Insights on aging and exceptional longevity from longitudinal data: novel findings from the Framingham Heart Study. Age (Dordrecht, Netherlands), 28(4), 363–374. https://doi.org/10.1007/s11357-006-9023-7
Yashin, Anatoli I., Igor V. Akushevich, Konstantin G. Arbeev, Lucy Akushevich, Svetlana V. Ukraintseva, and Aliaksandr Kulminski. “Insights on aging and exceptional longevity from longitudinal data: novel findings from the Framingham Heart Study.Age (Dordrecht, Netherlands) 28, no. 4 (December 2006): 363–74. https://doi.org/10.1007/s11357-006-9023-7.
Yashin AI, Akushevich IV, Arbeev KG, Akushevich L, Ukraintseva SV, Kulminski A. Insights on aging and exceptional longevity from longitudinal data: novel findings from the Framingham Heart Study. Age (Dordrecht, Netherlands). 2006 Dec;28(4):363–74.
Yashin, Anatoli I., et al. “Insights on aging and exceptional longevity from longitudinal data: novel findings from the Framingham Heart Study.Age (Dordrecht, Netherlands), vol. 28, no. 4, Dec. 2006, pp. 363–74. Epmc, doi:10.1007/s11357-006-9023-7.
Yashin AI, Akushevich IV, Arbeev KG, Akushevich L, Ukraintseva SV, Kulminski A. Insights on aging and exceptional longevity from longitudinal data: novel findings from the Framingham Heart Study. Age (Dordrecht, Netherlands). 2006 Dec;28(4):363–374.
Journal cover image

Published In

Age (Dordrecht, Netherlands)

DOI

EISSN

1574-4647

ISSN

0161-9152

Publication Date

December 2006

Volume

28

Issue

4

Start / End Page

363 / 374

Related Subject Headings

  • Gerontology
  • 52 Psychology
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 17 Psychology and Cognitive Sciences
  • 11 Medical and Health Sciences
  • 06 Biological Sciences