Cancer in rodents: does it tell us about cancer in humans?

Journal Article (Review;Journal Article)

Information obtained from animal models (mostly mice and rats) has contributed substantially to the development of treatments for human cancers. However, important interspecies differences have to be taken into account when considering the mechanisms of cancer development and extrapolating the results from mice to humans. Comparative studies of cancer in humans and animal models mostly focus on genetic factors. This review discusses the bio-epidemiological aspects of cancer manifestation in humans and rodents that have been underrepresented in the literature.

Full Text

Duke Authors

Cited Authors

  • Anisimov, VN; Ukraintseva, SV; Yashin, AI

Published Date

  • October 2005

Published In

Volume / Issue

  • 5 / 10

Start / End Page

  • 807 - 819

PubMed ID

  • 16195752

Electronic International Standard Serial Number (EISSN)

  • 1474-1768

International Standard Serial Number (ISSN)

  • 1474-175X

Digital Object Identifier (DOI)

  • 10.1038/nrc1715

Language

  • eng