What evidence is there for the existence of individual genes with antagonistic pleiotropic effects?

Journal Article (Review;Journal Article)

Classical evolutionary theory predicts the existence of genes with antagonistic effects on longevity and various components of early-life fitness. Quantitative genetic studies have provided convincing evidence that such genes exist. However, antagonistic pleiotropic effects have rarely been attributed to individual loci. We examine several classes of longevity-assurance genes: those involved in regulation of the gonad; the insulin-like growth factor pathway; free-radical scavenging; heat shock proteins and apoptosis. We find initial evidence that antagonistic pleiotropic effects are pervasive in each of these classes of genes and in various model systems--although most studies lack explicit studies of fitness components. This is particularly true of human studies. Very little is known about the early-life fitness effects of longevity loci. Given the possible medical importance of such effects we urge their future study.

Full Text

Duke Authors

Cited Authors

  • Leroi, AM; Bartke, A; De Benedictis, G; Franceschi, C; Gartner, A; Gonos, ES; Fedei, ME; Kivisild, T; Lee, S; Kartaf-Ozer, N; Schumacher, M; Sikora, E; Slagboom, E; Tatar, M; Yashin, AI; Vijg, J; Zwaan, B

Published Date

  • March 2005

Published In

Volume / Issue

  • 126 / 3

Start / End Page

  • 421 - 429

PubMed ID

  • 15664630

Electronic International Standard Serial Number (EISSN)

  • 1872-6216

International Standard Serial Number (ISSN)

  • 0047-6374

Digital Object Identifier (DOI)

  • 10.1016/j.mad.2004.07.012


  • eng