Central and peripheral effects of insulin/IGF-1 signaling in aging and cancer: antidiabetic drugs as geroprotectors and anticarcinogens.

Journal Article

Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the development of cancer. Insulin/insulin-like growth factor 1 (IGF-1) signaling molecules linked to longevity include DAF-2 and insulin receptor (InR) and their homologues in mammals and to inactivation of the corresponding genes followed by increased life span in nematodes, fruit flies, and mice. It is possible that the life-prolonging effect of caloric restriction are due to decreasing IGF-1 levels. A search of pharmacological modulators of life span-extending mutations in the insulin/IGF-1 signaling pathway and mimetics of effects of caloric restriction could be a direction in the regulation of longevity. Some literature and our own observations suggest that antidiabetic drugs could be promising candidates for both life span extension and prevention of cancer.

Full Text

Duke Authors

Cited Authors

  • Anisimov, VN; Berstein, LM; Popovich, IG; Zabezhinski, MA; Egormin, PA; Tyndyk, ML; Anikin, IV; Semenchenko, AV; Yashin, AI

Published Date

  • December 2005

Published In

Volume / Issue

  • 1057 /

Start / End Page

  • 220 - 234

PubMed ID

  • 16399897

International Standard Serial Number (ISSN)

  • 0077-8923

Digital Object Identifier (DOI)

  • 10.1196/annals.1356.017

Language

  • eng

Conference Location

  • United States