Stressors and antistressors: how do they influence life span in HER-2/neu transgenic mice?

Journal Article (Journal Article)

The purpose of this study is to investigate possible influences of different stressors (saline injections, light deprivation and constant light regimen) and geroprotectors (Epitalon and melatonin) on survivals of female HER-2/neu transgenic mice. We propose a semi-parametric model of heterogeneous mortality (frailty model) for the analysis of the experimental data. In this model, we assume that treatment influences parameters of both frailty distribution and baseline hazard. The unique design of the experiments makes it possible to compare the effects on survival produced by different treatments in terms of changes in population heterogeneity and underlying hazard. Parameters of the model help to describe the possible influences of various stressors, geroprotectors, and their dosage on the life span of laboratory animals. The proposed model helps to advance our understanding of the effects--such as debilitation, longevity hormesis and incomplete hormesis--which occur in the population as a result of different treatments.

Full Text

Duke Authors

Cited Authors

  • Semenchenko, GV; Anisimov, VN; Yashin, AI

Published Date

  • October 2004

Published In

Volume / Issue

  • 39 / 10

Start / End Page

  • 1499 - 1511

PubMed ID

  • 15501020

Electronic International Standard Serial Number (EISSN)

  • 1873-6815

International Standard Serial Number (ISSN)

  • 0531-5565

Digital Object Identifier (DOI)

  • 10.1016/j.exger.2004.08.007


  • eng